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NA has similar potency at the α1- and α2-receptors. A, Dose-response curves for the NA-induced depolarization in idaxozan (α1-mediated effect, open circles) and for the NA-induced hyperpolarization in prazosin (α2-mediated effect, filled circles) in primary cells. B, Dose-response curves for the α1-receptor-mediated depolarization by NA (filled circles) and by PE (filled squares) in NRM cells without the composite NA response.
