Figure 6.

Effects of glucose analogs on goldfish RGCs. a, Of the analogs tested, only d-glucosamine (25 μm) stimulated axon outgrowth. glc, Glucose; pyran, pyranoside; Ac, acetyl. b, Outgrowth is not altered by MH, an inhibitor of glucose-6-kinase and hexose-6-kinase. Inset, MH decreases cell survival (c/f, viable RGCs per field). c, The 6-phosphate derivatives of d-glucose and d-mannose (glc-6-P, man-6-P) stimulate outgrowth when present at 10-fold higher concentrations than the parent hexoses. y-axis is the same as in b. ^**p < 0.01, ^***p < 0.001 relative to cells grown in media alone: ^††p < 0.01 decrease in survival relative to glucose alone.