Figure 2.

CAA and associated microhemorrhage occur in both the aged APPsw and PDAPP mice. A, B, Prussian Blue staining indicates microhemorrhage in an 18-month-old APPsw mouse and 24-month-old PDAPP mouse, respectively. C, D, Thioflavine-S-positive vessels (arrows) in an 18-month-old APPsw mouse and 24-month-old PDAPP mouse, respectively. E, F, Merged images of A and C and B and D showing colocalization of microhemorrhage (red) with CAA (green). Prussian Blue images were digitally converted to red using Adobe Photoshop. Scale bar, 100 μm.