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. 2003 Aug 27;23(21):7889–7896. doi: 10.1523/JNEUROSCI.23-21-07889.2003

Figure 3.

Figure 3.

Age-dependent CAA and microhemorrhage in APP transgenic mice is prevented in the absence of apoE. A, CAA load increases with age in the cortex of 12-, 15-, and 18-month-old APPsw, Apoe+/+ mice. APPsw, Apoe-/- mice have a significant reduction (p < 0.05) in CAA at 15 and 18 months. B, The frequency of microhemorrhage also increases in 12-, 15-, and 18-month-old APPsw, Apoe+/+ mice. APPsw, Apoe-/- mice have a significant reduction (p < 0.05) in microhemorrhage at 15 and 18 months. C, CAA load increases in the cortex between 15 and 24 months of age in PDAPP, Apoe+/+ mice. PDAPP, Apoe-/- mice have a significant reduction (p < 0.05) in CAA at 15 and 24 months of age as compared with PDAPP, Apoe+/+ mice. D, The frequency of microhemorrhage increases in 15- and 24-month-old mice. PDAPP, Apoe-/- mice have a significant reduction (p < 0.05) in microhemorrhage at 15 and 18 months as compared with PDAPP, Apoe+/+ mice.