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. 2003 Aug 27;23(21):7889–7896. doi: 10.1523/JNEUROSCI.23-21-07889.2003

Figure 5.

Figure 5.

Ratio of Aβ 40:42 is increased in cerebral blood vessels of APPsw and PDAPP mice shown in Table 2. Shown is immunoblot of cerebral vessels and parenchymal brain tissue lysates run on acid-urea polyacrylamide gels to differentiate Aβ 1-40 and 1-42. Both the 18-month-old APPsw and 24-month-old PDAPP mice tested revealed an elevated ratio of Aβ 40:42 in cerebral vessel lysates as compared with brain parenchyma. Immunoblots were probed with an anti-Aβ antibody mixture of 3D6 (N-terminal specific), 21F12 (42 specific), and 266 (central domain specific). WB, Whole brain; V, vessels; P, parenchyma.