Table 1.
Comparison of Aβ levels and parenchymal plaque load between APPsw and PDAPP models
|
|
Aβ 40 pg/μg |
Aβ 42 pg/μg |
Aβ 40 + 42 pg/μg |
Aβ 40:42 ratio |
% Non-CAA Aβ load |
|---|---|---|---|---|---|
| APPsw | |||||
| 3 months | 5.8* | 5.3 | 11.1 | 1.30* | 0 |
| 11-12 months | 115.3* | 46.8 | 162.1 | 2.34* | 2.56* |
| 15-16 months | 267.1* | 118.7* | 385.9* | 2.22* | 19.37 |
| PDAPP | |||||
| 3 months | 1.8 | 3.72 | 5.47 | 0.46 | 0 |
| 11-12 months | 27.4 | 449.9 | 477.3 | 0.08 | 19.67 |
| 15-16 months
|
84.7
|
920.2
|
1004.9
|
0.10
|
28.88
|
Aβ ELISA analysis (pg/μg) of hippocampal lysates from both APPsw and PDAPP mice reveals an elevated ratio of Aβ 40:42 in APPsw mice at all ages examined. PDAPP mice have a higher parenchymal (non-CAA) plaque load than APPsw mice. *p < 0.05 comparing APPsw with PDAPP mice at the same age (n ≥ 4 per group).