Figure 1.
Modulation of IL-1ra release by LPS and CB antagonists and agonists in primary mixed glial cultures from C57BL/6 (WT) mice. Mixed glial cultures were treated with medium (Control) or LPS in the presence or absence of HU-210, CP-55940, SR-141716A, or SR-144528. a, Effect of LPS and SR-141716A or SR-144528 on IL-1ra release. b, Effect of LPS and HU-210 on IL-1ra release. c, Effect of LPS and CP-55940 on IL-1ra release. Data are presented as mean ± SEM of four independent experiments on separate cultures, each performed in triplicate. Statistical differences (one-way ANOVA and Newman-Keuls multiple test): *p < 0.001 versus control; #p < 0.001 versus LPS.