Figure 3.

Unitary properties of KARs. The single-channel conductance (γ) of somatic (A) and dendritic (B) KARs was estimated by nonstationary fluctuation analysis. Consistent with the identical unitary properties of somatic and dendritic KARs, statistical evaluation revealed no significant difference between γ of somatic and γ of dendritic KARs (C). A,B show single experiments. D, The kinetics of KAR-mediated responses were examined by spectral analysis. Fits of sums of Lorentzian functions to the variance power spectra showed that the data can be described best by a single Lorentzian function. The presence of only a single corner frequency agrees well with the observation that, in the time domain, the decay phase of the evoked currents can be best fit monoexponentially. The mean time constants obtained by both ways are nearly identical.