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. 2003 Jul 23;23(16):6651–6659. doi: 10.1523/JNEUROSCI.23-16-06651.2003

Figure 1.

Figure 1.

Presence of a chemoattractive activity in the OB. A, A diagram of the sagittal section of neonatal rat forebrain. X, SVZa; Y, region of neocortex from which cortical explants were isolated and used in C; Z, tip of the OB from which explants were isolated and used in D-G. B, An SVZa explant was cultured for 24 hr. Cells migrated symmetrically from the explant. C, Coculture of an SVZa explant with a neocortical explant (CTX). Migrating SVZa cells were symmetrically distributed around the circumference of the SVZa explant (n = 129 of 137). D, Effect of the OB on the migration of cells from SVZa explants. Asymmetric distribution of migrating cells with a higher number of cells in the quadrant proximal to the OB than that in distal quadrant (n = 539 of 627) is shown. Scale bar, 100 μm. E, The same explant as in D, showing staining with the TuJ1 antibody. F, The same explant as in D, showing staining with anti-GABA antibodies. G, Superimposition of E and F. H, Effects of cortical and OB explants on the distribution of SVZa cell migration. Proximal/distal ratios were calculated from the numbers of cells in the proximal quadrants divided by those in the distal quadrants. Cell numbers were counted from 33 cocultures with the OB explants and 16 cortical (CTX) explants. CTX, Cortex.