Figure 6.

Melanopsin is expressed in a subpopulation of RGCs that project to the LGN. A, Camera lucida drawing of a coronal brain section from FG-injected animals. The IGL is thickly outlined, and smoothly drawn lines indicate injection sites. Gray regions indicate brain regions that receive heavy input from the retina, and horizontal lines indicate the optic tract. B-D, Case 2455. Injections of FG in the LGN that included the IGL (B) resulted in retrogradely labeled RGCs in the ipsilateral eye (C) that were also positive for melanopsin transcript (D). Arrows indicate a double-labeled cell. AcR, Acoustic radiation; OT, optic tract. Scale bars: A, 500 μm; B, 200 μm; C, D, 50 μm.