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PrPC is not enriched in astrocytes in the hippocampus. A, B, A strocyte and astrocytic process. Double labeling for PrPC (small particles) and GFAP (large particles) is shown. Both labels were enhanced with silver. PrPC is more concentrated on neuropil membranes (white arrowheads) than on astrocytic membranes (black arrows). The dashed line in A delineates the astrocytic plasma membrane. er, Endoplasmic reticulum; m, mitochondria; n, nucleus. Scale bars, 200 nm.
