Figure 6.
Activation of group III mGluRs inhibits striatopallidal transmission in reserpinized animals. Shown are representative traces (A) and time course (B) of the effects of group III agonists on striatopallidal transmission in slices from animals that received an 18-20 hr reserpine treatment. C, Summary data illustrating the effect of reserpine treatment on l-AP4-induced inhibition of transmission at the striatopallidal synapse. Although the effect of l-AP4 was significantly smaller in slices from reserpinized animals (†p < 0.01; n = 4-7; t test corrected for planned multiple comparisons), it was still highly significant (*significant effect of l-AP4, p < 0.01; n = 4-7; t test corrected for planned multiple comparisons).