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. 2003 Aug 6;23(18):7218–7226. doi: 10.1523/JNEUROSCI.23-18-07218.2003

Figure 7.

Figure 7.

Activation of group III mGluRs produces antiparkinsonian actions in both acute and chronic rodent models of PD. A, Effects of vehicle (PBS, intracerebroventricular) and increasing doses of l-AP4 (5, 50, and 100 nmol, i.c.v.) on haloperidol-treated rats (n = 4-7 animals per group). Catalepsy was measured using a rectangular vertical grid. **p < 0.01 compared with vehicle group. B, Effects of l-AP4 (50 nmol, i.c.v.) and vehicle (PBS, intracerebroventricular) on reserpine-treated rats (n = 4-7 animals per group). *p < 0.05 compared with vehicle group. C, Effects of l-AP4 (100 nmol, i.c.v.) and l-DOPA (6 mg/kg, i.p.) on forelimb asymmetry in unilateral 6-OHDA-lesioned rats (n = 4 animals per group). Asymmetry score = [% ipsilateral paw - (% contralateral paw + % both paws)]. Positive asymmetry scores reflect preferential use of the forelimb ipsilateral to the lesion site. Negative asymmetry scores, or scores approaching zero, reflect a lack of ipsilateral bias relative to the use of the contralateral forelimb or simultaneous use of both forelimbs. *p < 0.05 (l-AP4); **p < 0.01 (l-DOPA), compared with corresponding pretreatment groups.