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Synopsis of cyclic changes in the hippocampal mossy fiber system and CA3 target neurons during hibernation obtained by densitometrical analysis on immunohistochemical preparations, processed in parallel. An inverse cyclic relationship is observed between presynaptic markers (PSA-NCAM, synaptophysin) and postsynaptic markers (MAP2) in the stratum lucidum on one side and PHF-like tau (AT8) in somata of CA3 pyramidal neurons on the other side.
