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Immunohistochemical detection of PHF-like phosphorylated tau by the monoclonal antibody AT8 in long torpor (middle) as compared with a non-hibernating euthermic animal (left) and an animal after long arousal (right). Note the strong reactivity in the entorhinal cortex (arrowheads), hippocampus, cortex, as well as hypothalamic and epithalamic nuclei in torpor and its complete reversal within hours after arousal. Scale bar, 1 mm.
