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. 2003 Aug 6;23(18):7084–7092. doi: 10.1523/JNEUROSCI.23-18-07084.2003

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Copyright © 2003 Society for Neuroscience 0270-6474/03/237084-09.00/0

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Figure 4. — Igf1r heterozygosity causes a further reduction in brain size in Irs2^-/- mice. a, Brain size of 6-week-old wild-type (wt), Igf1r^+/-, Irs2^+/-, Irs2^+/-Igf1r^+/-, Irs2^-/-, and Igf1r^+/-::Irs2^-/- mice. b, Brain-body ratio (%) of 6-week-old mice of the different genotypes. c, BrdUincorporation in cerebella granule cells at P6 (48 hr survival) from wild type, Irs2^-/-, or Irs2^-/-Igf1r^+/-. Cell counts and average cell size were calculated with NIH ImageJ. d, Apoptosis in the cerebella granule cells from Igf1r^+/-, Irs2^+/-Igf1r^+/-, and Irs2^-/-Igf1r^+/- mice (P5). Granule cells were cultured for 4 d and then incubated for an additional 24 hr in serum-free medium containing 5 mm KCl,5mm KCl plus 10 nm IGF1,5 mm KCl plus 50 ng/ml BDNF. pvalues were calculated using Sigmaplot (Sigma, St. Louis, MO) version 8.1.