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. 2003 Sep 10;23(23):8302–8309. doi: 10.1523/JNEUROSCI.23-23-08302.2003

Figure 2.

Figure 2.

Effects of chronic MPEP treatment on behavioral parameters measured in the reaction time task. a, Percentage of delayed responses for each experimental group ± SEM (sham, n = 6; 6-OHDA, n = 7; 0.75 mg/kg MPEP, n = 7; 1.5 mg/kg MPEP, n = 6; 3 mg/kg MPEP, n = 9; 6 mg/kg MPEP, n = 10) measured for the last RT session (day 32). Whereas MPEP chronic treatment at the lowest and highest doses (0.75 and 6 mg/kg) just partially improved recovery of performance, MPEP at doses of 1.5 and 3 mg/kg allowed a total recovery. ❖ , Significant difference from control group (p < 0.05; Scheffé's test after significant ANOVA); #, significant difference from 6-OHDA-nontreated group (p < 0.05; Scheffé's test after significant ANOVA). b, Mean RT ± SEM for one preoperative session (day -1) and two postoperative sessions corresponding to the lesion effect without treatment (day 14) in comparison with the last day of chronic treatment (day 32) and measured for the 6-OHDA, 1.5 mg/kg MPEP, and 3 mg/kg MPEP groups. At day 32, mean RTs were shortened by MPEP chronic treatment and significantly differed from the control-lesioned group injected with vehicle. ❖, Significant difference from preoperative performance for each group (p < 0.05; Scheffé's test after significant ANOVA); #, significant difference from 6-OHDA group at D32 (p < 0.05; Scheffé's test after significant ANOVA).