Figure 6.

Pharmacological profile of depolarization-induced calcium signals. A, Effect of an L-type calcium channel agonist on depolarization-elicited fluorescence intensity changes of OG5 in the lobular appendages. Calcium transients in response to a 250 msec depolarization were recorded in control conditions, after perfusion with 10 μm BayK 8644 and after a washout. BayK 8644 almost doubled the change in fluorescence, and this effect was reversible. B, Effect of L-type calcium channel antagonists on depolarization-evoked calcium transients of the lobular appendages detected with OG5. Calcium rises induced by a 250 msec depolarizing pulse were largely blocked by 10 μm nitrendipine.