Figure 5.

Sensitivity of Aβ-evoked Ca²⁺ increases in isolated hippocampal nerve endings to nicotinic receptor antagonists. Average maximal responses Ca²⁺ responses to Aβ_1-42 in the absence or presence of 500 nm α-bungarotoxin (BgTx; A) (100 pm, n = 14; 100 nm, n = 22), 10 μm mecamylamine (Mec; B) (100 pm, n = 14; 100 nm, n = 14), 500 nm α-bungarotoxin plus 10 μm mecamylamine (Bg/Mec; C) (100 pm, n = 12; 100 nm, n = 6), or 5 μm dihydro-β-erythroidine (DHβE; D) (100 pm, n = 22; 100 nm, n = 16). ^*p < 0.05; t test with paired control.