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. 2003 Aug 20;23(20):7659–7669. doi: 10.1523/JNEUROSCI.23-20-07659.2003

Figure 4.

Figure 4.

Extrasynaptic and synaptic plasma membrane-apposed group I mGluR immunogold labeling in the monkey striatum. A, Relative proportion of extrasynaptic versus synaptic plasma membrane-apposed gold particles for group I mGluRs in different compartments of striatal neurons. Mean values (±SD) from three animals (n) were used. The distribution of gold-particle labeling for either receptor subtype in spines was significantly different (p < 0.05; ANOVA with post hoc Newman-Keul) from that in dendrites and soma. The total numbers of gold particles (g) and neuronal elements (e) examined in three animals were as follows: mGluR1a spines, 419 (g) and 263 (e); mGluR5 spines, 465 (g) and 287 (e); mGluR1a dendrites, 892 (g) and 634 (e); mGluR5 dendrites, 1593 (g) and 843 (e); mGluR1a soma, 342 (g) and 70 (e); and mGluR5 soma, 1042 (g) and 25 (e). Error bars indicate SD. B, Distance between extrasynaptic plasma membrane-apposed gold-particle labeling for mGluR5 and the closest edge of asymmetric postsynaptic specializations. Serial sections of asymmetric synapses established by anterogradely labeled boutons from the cortex and thalamus were used in this analysis. The total number of gold particles and synapses examined is indicated in parentheses. The axospinous synapses are established by cortical terminals, whereas axodendritic synapses involve thalamostriatal boutons. Note that the majority of gold particles are located <0.5 μm away from either population of putative glutamatergic synapses.