Figure 7.

Action potential-mediated synaptic transmission from granule cells to mitral cells is reduced by a T-type calcium channel antagonist. A, Experimental stimulation and recording scheme. Granule cells are stimulated extracellularly, whereas a mitral cell is being recorded from in whole-cell mode. B, Mibefradil reduces synaptic transmission. Traces from an individual experiment show averaged data (∼20 sweeps each) of the baseline IPSP (thick trace) and 15 min after application of 10 μm mibefradil (thin trace). C, Average reduction of synaptic transmission by mibefradil (n = 6 for control and mibefradil application, n = 3 for bicuculline application). Data are shown with SD.