Figure 3.

Effects of different forms of sensory deprivations applied during P14-P21 on the heat-nociceptive withdrawal reflex adaptation. Comparisons were made between all groups at P21. All significant differences are indicated. The gray bars signify treatment with deprived or absent nociceptive input but preserved tactile sensitivity. The black bar signifies treatment that produced anesthesia. Solid lines indicate comparisons with the group treated with tube-EMLA and depilation; ^*p < 0.05; ^**p < 0.01; ^***p < 0.001. Dotted lines indicate comparisons with the control group; ⁺p < 0.05; ⁺⁺⁺p < 0.001. The χ² test was used for statistics. Corrections for multiple comparisons were made using the Bonferroni method. NWR, Nociceptive withdrawal reflex.