Figure 5.
Effect of anti-inflammatory drugs on Aβ40 and Aβ42 generation in APP-overexpressing cells. Human embryonic kidney 293 cells stably expressing full-length human APP695 were treated for 18-24 hr with the indicated concentration of ibuprofen or pioglitazone, and the medium was collected. Aβ42, Aβ40, and αAPPs levels were quantitated by standard sandwich ELISA. A, Ibuprofen, Aβ40 (□), Aβ42 (▪), and αAPPs (•), levels are shown ± SD. B, Pioglitazone, Aβ40 (□), Aβ42 (▪), and αAPPs (•) levels are shown ± SD.