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. 2003 Aug 20;23(20):7451–7460. doi: 10.1523/JNEUROSCI.23-20-07451.2003

Figure 1.

Figure 1.

Suppressive effects of intra-DRN microinjection of 5-HT antagonists on SCN 5-HT release evoked by electrical DRN stimulation. A, Metergoline (MET; n = 6). B, DR4004 (n = 5). Both drug treatments abolished the stimulated 5-HT release seen in vehicle (VEH) controls (n = 6, n = 5, respectively). These antagonists also suppressed basal SCN 5-HT output by ∼25% when injected into the DRN alone without electrical stimulation (C; n = 4 per group). ap < 0.05 versus pretreatment baseline levels; *p < 0.05 versus vehicle controls for a given time point. The 20 min period of electrical stimulation is represented by the horizontal bars designated STIM; INJ, drug or vehicle injection. Data are mean ± SEM.