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. 2003 Jun 1;23(11):4667–4676. doi: 10.1523/JNEUROSCI.23-11-04667.2003

Figure 7.

Figure 7.

Enhanced anxiety-like behaviors in heterozygous adult mice. A–D, Light/dark test. A, Total path length in the light compartment (white) in the light/dark test.B, Total length of time spent in the light compartment of the light/dark test.C, Latency to first entry to the light compartment in the light/dark test. D, Number of transitions between the light and dark compartments in the light/dark test. A–D, n = 11 for each genotype. E, Total path length in the open-field test (n = 16 for each genotype). F, G, Elevated-plus maze. F, Percentage of time in the open arms of the elevated-plus maze. G, Percentage entries into the open arms of the elevated-plus maze. F, G, n = 11 for each genotype. H, Freezing time in conditioned fear paradigms (n = 8 for each genotype and treatment). C, Control mice without foot shock; F, mice that received foot shock during conditioning. Solid bar represents wild-type mice; hatched bar represents heterozygous mice. Error bars indicate SEM. NS, Not significant. *p < 0.05; **p < 0.01.