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SDF-1 enhances the survival of embryonic mouse RGCs. After 24 (A; p = 0.001) or 72 (B; p = 0.005) hr in culture, an increased percentage of RGCs survive in the presence of 100 ng/ml SDF-1. p values were calculated by comparing each population with the untreated one using a two-tailed test with different variances. C, CXCR4 mRNA is expressed in the RGC cell layer of E13.5 mouse retina. D, At the same embryonic stage, SDF-1 mRNA is expressed in connective tissues surrounding the eye.
