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Nicastrin is important for the association of APP with PS1–γ-secretase complex. A, Nct RNAi leads to a significant inhibition of nicastrin expression in the cells. B, A decrease in the FITC–PS1 lifetime in APP–PS1 double-immunostained cells is observed in mock-treated cells, indicating a close proximity between the two proteins. This association is eliminated by Nct RNAi treatment because the FITC lifetime becomes the same as in the PS1–FITC alone control.
