Skip to main content
. 2003 Oct 8;23(27):9107–9115. doi: 10.1523/JNEUROSCI.23-27-09107.2003

Figure 7.

Figure 7.

In the presence of the 5-HT1a/b antagonists WAY-100135 (4 mg/kg) and GR-55562 (5 mg/kg) and the 5-HT2 antagonist LY-53857 (5 mg/kg), there was a partial reversal of the inhibitory effect of MDMA (12 mg/kg) on motor activity in l-DOPA-treated animals (a, d) (*p < 0.05). The 5-HT1b antagonist GR-55562, but not the 5-HT1a antagonist WAY-100135, partially reversed motor disability and dyskinesia in animals treated with l-DOPA and MDMA (*p < 0.05). The 5-HT2 antagonist LY-53857 failed to affect motor disability and dyskinesia in animals treated with l-DOPA and MDMA.