Figure 10.

Morphology of hair bundles and hair cells in Ptprq-TM-KO and Ptprq-CAT-KO mice. a-f, Survey scanning electron micrographs at P8 (a-d) and sections at P22 (e, f) of the organ of Corti in the basal coil of heterozygous (a, c, e) and homozygous (b, d, f) Ptprq-CAT-KO (a, b) and Ptprq-TM-KO (c-f) mice. The hair bundles of inner (arrows) and outer (arrowheads) hair cells are considerably affected in both the homozygous Ptprq-CAT-KO (b) and the Ptprq-TM-KO (d) mice by P8. Note the difference in the shape of the outer hair-cell hair bundles. Hair cells are still present in the organ of Corti in Ptprq-TM-KO mice at P22 (e, f). Scale bars: (in d) a-d, 5 μm; (in f) e, f, 20 μm.