Figure 5.

Expression of Ptprq during mouse inner ear development. Pairs of fluorescence micrographs from adjacent sections of the vestibule at E13.5 (a, a′) and P21 (e, e′) and the cochlea at E18.5 (b, b′), P2 (c, c′), and P21 (d, d′) labeled with antibodies to myosin VIIa (a-e) or Ptprq (a′-e′). Ptprq first appears in the vestibule at E13.5 (a′) and is present on inner and outer hair cells in the base of the cochlea by E18.5 (b, b′). Ptprq expression on basal-coil outer hair cells increases by P2 (c, c′) but declines by P15 and can no longer be detected at P21 (d′). Inner hair cells (d′) and vestibular hair cells (e′) express Ptprq into maturity. Scale bars, 20 μm.