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KOR agonist inhibition of VTA neurons is postsynaptic and mediated by GIRK activation. A, In the presence of TTX (500 nm) to block neural activity, U69593 causes hyperpolarization in an example cell. B, In recordings made without TTX, the difference between control and U69593 (1 μm) current-voltage curves during a voltage ramp test shows inward rectification and a reversal potential of -93 mV (n = 7; 95% confidence interval indicated in gray).
