Skip to main content
. 2003 Oct 29;23(30):9929–9936. doi: 10.1523/JNEUROSCI.23-30-09929.2003

Figure 5.

Figure 5.

Iontophoretic application of bicuculline blocks the inhibitory effect induced by STN high-frequency stimulation at low intensity on the activity of a SNR cell. The efficiency of bicuculline to block the GABAergic transmission is ascertained by its ability to reverse the effect of iontophoretic application of GABA. Although the GABA response is blocked, STN high-frequency stimulation (130 Hz; 5 V) is no longer able to decrease the spontaneous activity of the SNR cell. After cessation of bicuculline application, the inhibitory effect of STN stimulation concomitantly recovered with the sensitivity of the cell to GABA. Horizontal lines indicate the time of GABA and/or bicuculline iontophoretic application and the time of STN high-frequency stimulation application, as indicated by the corresponding headlines.