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. 2003 Oct 29;23(30):9937–9946. doi: 10.1523/JNEUROSCI.23-30-09937.2003

Figure 5.

Figure 5.

Voltage-dependent amplification of sEPSP input in vSUB pyramidal neurons after early or late withdrawal from repeated saline or amphetamine treatment. A and B show scatter plots of the near-threshold peak and integral amplification in RS and BS neurons from the SAL/EW control (top panels) and AMPH/EW groups (bottom panels) groups. Both groups exhibited significant voltage-dependent amplification of the sEPSPs (p < 0.001). No differences in the amplification distribution between RS and BS neurons in either drug group at either withdrawal time were detected; therefore they were pooled for the drug comparisons (SAL/EW, □; AMPH/EW, ▪). C shows an amphetamine-induced reduction in the peak and integral of near-threshold amplification of the sEPSP in the AMPH/EW group (SAL, n = 12; AMPH, n = 12; **p<0.01; *p<0.05; see Appendix). Scatter plots for the late withdrawal time are not shown because there were no treatment group differences, and the scatter for RS and BS neurons was similar to those shown for the early withdrawal (A, B). D shows the return to normal near-threshold peak (left) and integral (right) amplification of the sEPSP in SAL/LW and AMPH/LW groups. All groups consisted of 6–12 cells.