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. 2003 Oct 29;23(30):9796–9804. doi: 10.1523/JNEUROSCI.23-30-09796.2003

Figure 3.

Figure 3.

Effect of Ibuprofen (IBU) and pioglitazone (PIO) on APP secretion. A, IBU and PIO decrease total sAPP (APPs) and α-sAPP (α-APPs) levels in N2a cells immunostimulated with proinflammatory cytokines but not under noninflammatory conditions. B, Quantification of sAPP by Western blot in six different experiments. C, Quantification of intracellular full-length APP by Western blotting shows no difference among treatments. Columns represent average ± SEM. Asterisks indicate significant differences between control and treatment. Number signs indicate significant differences between treatment with cytokines alone and with NSAIDs. **p ≤ 0.01; ***p ≤ 0.001; #p ≤ 0.05; ###p ≤ 0.001; ANOVA followed by a Tukey's post hoc test. C, Control.