Figure 9.

3-AB prevented hypoglycemia-induced spatial learning and memory impairments assessed 6 weeks after hypoglycemia. Rats were treated with 30 min EEG isoelectricity with (n = 8) or without (n = 8) 30 mg/kg 3-AB administered at the time of glucose correction, or with sham surgery only (n = 6). A, During both the visible and hidden platform sessions, rats subjected to hypoglycemia showed a significant impairment in ability to locate the platform when compared with either the sham-treated or 3-AB-treated animals (^**p < 0.01). B, In the probe trial, in which the platform was removed from the tank, both sham-operated and 3-AB-treated groups spent significantly more time searching in the target quadrant than in any of the other quadrants (^*p < 0.05), whereas the hypoglycemia only group did not.