Table 1.
Comparison of baclofen and CP55940 effects on destaining of GABAergic boutons as a function of stimulation frequency and VGCC subtype-mediating release
|
|
2 Hz stimulation |
10 Hz stimulation |
||||||
|---|---|---|---|---|---|---|---|---|
|
|
Non-DS percentage
|
τdestain
|
Non-DS percentage
|
τdestain
|
f
|
|||
| AgTx-pretreated cultures (release mediated by N-type VGCCs) | ||||||||
| GABABR | ↑ | ↑ | No change | ↑ | ↓ | |||
| CB1R | ↑ | ↑ | No change | ↑ | No change | |||
| CTx-pretreated cultures (release mediated by PQ-type VGCCs) | ||||||||
| GABABR | ↑ | No change | No change | No change | n.t. | |||
| CB1R
|
No change
|
No change
|
n.t.
|
n.t.
|
n.t.
|
|||
Non-DS percentage, percentage of boutons classified as nondestaining; τdestain, mean rate of destaining from individual boutons; f, increase in facilitation ratio measured between 150 and 300 stimuli; ↑, ↓, denote statistically significant change from control value; No change, no statistically significant change from control value; n.t., not tested.