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. 2003 Nov 19;23(33):10568–10576. doi: 10.1523/JNEUROSCI.23-33-10568.2003

Figure 7.

Figure 7.

Genetic regulation of ventral pallial identity. A, Dbx1 is a marker of the ventral pallium. B, In the Gsh2 mutant, Dbx1 is ectopically expressed in the LGE. C, This is also the case in the Gsh2/Tlx double mutant; however, the number of cells expressing Dbx1 is drastically reduced. Note that, although Dbx1 is expressed in the LGE-cortex angle in the wild type, this area lacks expression of Dbx1 in the Gsh2 mutant and Gsh2/Tlx double-mutant telencephalon. Another marker of the ventral pallium, SFRP2, is expressed in the LGE-cortex angle at E12.5 (arrow in D). At this stage, the location of the SFRP2 expression domain is shifted ventrally in Gsh2 mutants (open arrow) compared with its normal position (arrow). F, In the Gsh2/Tlx double mutant, SFRP2 expression is missing. G, Also at E14.5, SFRP2 expression is detected in the LGE-cortex angle (arrow in G). H, After the recovery, which is occurring in Gsh2 mutants by E14.5, SFRP2 expression is undistinguishable from the wild type. I, However, in a Gsh2/Tlx double mutant, SFRP2 expression is still missing. KO, Knock-out.