Figure 8.

Some aspects of ventral pallial identity are retained even in the absence of Tlx and Gsh2. A, B, In a wild type, Tbr1 (A) and Lhx2 (C) are expressed in the entire pallial SVZ and the ventral pallium SVZ, respectively. B, In Gsh2/Tlx double mutants, SVZ expression of Tbr1 is expanded into the LGE, showing that not only the VZ adopts a pallial identity. D, In addition, Lhx2 expression in the SVZ is shifted into the LGE, showing that, despite the lack of SFRP2 and Dbx1 in the VZ, aspects of ventral pallial identity are still retained in the double mutants. Filled arrows mark the pallio-subpallial boundary in wild types. Open arrows mark the ventral shift of this boundary in the double mutants. KO, Knock-out.