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. 2003 Dec 17;23(37):11698–11710. doi: 10.1523/JNEUROSCI.23-37-11698.2003

Figure 5.

Figure 5.

Mutation of β3 (S407A,S408A) decreased desensitization and accelerated deactivation, whereas β3(S407E, S408E)-containing receptors did not differ from wild type. Wild-type α1β3γ2L receptors were compared with α1β3(S407A,S408A)γ2L (β3AA receptors), α1β3(S407E,S408A)γ2L (β3EA), α1β3(S407A,S408E)γ2L (β3AE), and α1β3(S407E,S408E)γ2L (β3EE receptors) mutant receptors. Currents were normalized to peak. Initially, we compared β3AA receptors and β3EE receptors with wild type. A 400 msec GABA (1 mm) application to β3AA and β3EA receptors resulted in a decreased desensitization and accelerated deactivation compared with wild-type, β3EE, and β3AE GABA receptors. A 6 sec GABA (1 mm) application to β3AA and β3EA receptors resulted in an decreased desensitization and accelerated deactivation compared with wild-type β3EE, and β3AE GABA receptors.