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. 2003 Dec 17;23(37):11698–11710. doi: 10.1523/JNEUROSCI.23-37-11698.2003

Figure 7.

Figure 7.

Brief (5 msec) GABA application response durations were modulated by mutation of β3 subtype serine 407 and 408 to alanine. GABA (1 mm) was applied to excised macropatches for 5 msec. A, Representative data traces are displayed for α1β3γ2L, α1β3(S407A,S408A)γ2L (β3AA), and α1β3(S407A,S408A)γ2L (β3EE) receptors. B, Data from A are normalized to peak and overlaid for comparison showing faster deactivation for β3AA receptors and slower deactivation for β3EE receptors compared with wild-type receptors. Deactivation was accelerated in β3AA receptor currents compared with β3EE and wild-type receptor currents. C, Representative data showing current deactivation after 400 msec and 6 sec GABA application. For purposes of comparison, the level of current at offset of GABA (arrow) is normalized, and most current in the presence of GABA has been excluded from the display. Deactivation was accelerated in β3AA receptor currents compared with β3EE receptor currents.