Figure 10.

Dopamine-induced inhibition of GABAergic outward currents absent in GP neurons of D4KO mice. A, Current-voltage relationships of IPSCs recorded from WT (open triangles; n = 12) and D4KO (filled triangles; n = 10) mice. Current amplitudes were normalized to the value obtained at 0 mV. The inset indicates representative IPSCs at each holding potential from WT and D4KO mice. Calibration: 0.2 nA, 40 msec. B, Normalized outward currents recorded from GP neurons in acute slices prepared from D4R-deficient (n = 10) or littermate WT (n = 8) mice. The filled bar indicates application of DA (10 μm). C, Summarized histograms show effects of DA on the amplitude of outward currents recorded from D4KO and WT mice. ^*p < 0.05; unpaired Student's t test.