Skip to main content
. 2003 Nov 26;23(34):10859–10866. doi: 10.1523/JNEUROSCI.23-34-10859.2003

Table 1.

Action potential properties of DA neurons after chronic haloperidol treatment




Half-width (msec)

First peak (mV)

Second peak (mV)

Threshold (mV)

AHP (mV)
Without TEA
Control 3.2 ± 1.4 33.1 ± 3.1 30.5 ± 2.1 −44.5 ± 0.9 −56.2 ± 1.5
Vehicle 3.3 ± 0.9 32.1 ± 3.4 32.4 ± 4.6 −45.0 ± 1.4 −57.9 ± 2.1
Haloperidol 4.3 ± 1.3 35.4 ± 3.2 33.6 ± 3.5 −46.1 ± 1.2 −58.9 ± 1.6
With TEA
Control 185 ± 62 21.0 ± 1.7 20.7 ± 2.4 −43.2 ± 2.4 −45.2 ± 2.6
Vehicle 155 ± 88 27.5 ± 2.6 25.7 ± 5.7 −38.9 ± 4.6 −48.4 ± 2.2
Haloperidol
126 ± 55
27.9 ± 1.5
24.6 ± 4.5
−40.5 ± 3.2
−53.7 ± 1.6

Half-width, The time between two peaks of first derivative; first peak, peak of the first spike; second peak, peak of the second spike; threshold, the first point on the rising phase of the spike where the rate of rise exceeded 20 mV/msec; AHP, afterhyperpolarization. n = 5-6.

HHS Vulnerability Disclosure