Table 1.
Action potential properties of DA neurons after chronic haloperidol treatment
|
Half-width (msec) |
First peak (mV) |
Second peak (mV) |
Threshold (mV) |
AHP (mV) |
---|---|---|---|---|---|
Without TEA | |||||
Control | 3.2 ± 1.4 | 33.1 ± 3.1 | 30.5 ± 2.1 | −44.5 ± 0.9 | −56.2 ± 1.5 |
Vehicle | 3.3 ± 0.9 | 32.1 ± 3.4 | 32.4 ± 4.6 | −45.0 ± 1.4 | −57.9 ± 2.1 |
Haloperidol | 4.3 ± 1.3 | 35.4 ± 3.2 | 33.6 ± 3.5 | −46.1 ± 1.2 | −58.9 ± 1.6 |
With TEA | |||||
Control | 185 ± 62 | 21.0 ± 1.7 | 20.7 ± 2.4 | −43.2 ± 2.4 | −45.2 ± 2.6 |
Vehicle | 155 ± 88 | 27.5 ± 2.6 | 25.7 ± 5.7 | −38.9 ± 4.6 | −48.4 ± 2.2 |
Haloperidol
|
126 ± 55
|
27.9 ± 1.5
|
24.6 ± 4.5
|
−40.5 ± 3.2
|
−53.7 ± 1.6
|
Half-width, The time between two peaks of first derivative; first peak, peak of the first spike; second peak, peak of the second spike; threshold, the first point on the rising phase of the spike where the rate of rise exceeded 20 mV/msec; AHP, afterhyperpolarization. n = 5-6.