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. 2003 Nov 26;23(34):10827–10831. doi: 10.1523/JNEUROSCI.23-34-10827.2003

Figure 2.

Figure 2.

DD mice did not increase locomotor behavior in response to repeated AMPH. A, DD mice (n = 12) were given l-dopa (50 mg/kg) at time 0, AMPH (2 mg/kg) at 24, 26, and 42 hr after l-dopa (filled arrowheads), and a control injection of PBS 44 hr after l-dopa (open arrowhead). The black bars indicate when room lights were off. The increased activity at 30 hr after l-dopa (white bar) is characteristic of DD mice (see Results). B, WT mice (n = 3) were treated as described for DD mice. C, Cumulative ambulations of WT (white columns) and DD (black columns) mice for 1.75 hr after AMPH or PBS at 24 (AMPH 1), 26 (AMPH 2), 42 (AMPH 3), and 44 (PBS 1) hr after l-dopa. *p < 0.05 compared with PBS value. D, DD and WT mice were given access to sucrose and water for 15 hr beginning 28 hr after the administration of l-dopa, either after AMPH at 24 and 26 hr (AMPH) or without previous AMPH administration (no AMPH). There was no difference in the total intake of DD or WT mice with or without previous AMPH administration.