Figure 1.

Effects of MMP inhibition on LTP in the crossed temporodentate system. A-C, Example field potentials evoked through the crossed perforant path. Pretetanus (top trace) and post-tetanus (bottom trace) waveforms are shown for an unlesioned control rat (A), a lesioned rat given intracerebral ventricular vehicle (B), and a lesioned rat given intracerebral ventricular FN-439 (C). Arrows indicate time of stimulus artifact. D, Group averages of tetanus-induced increases, expressed as percentage of pretetanus baseline, in fEPSP initial slope (left) and in population spike amplitude (right). ^*p < 0.05.