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. 2003 Nov 12;23(32):10351–10358. doi: 10.1523/JNEUROSCI.23-32-10351.2003

Figure 1.

Figure 1.

Effect of α-MSH and MC4R agonist on oxytocin neurons. A1, Example of reversible inhibition induced by α-MSH (200 ng, i.c.v.). A2, The mean change in firing rate (± SE) of five neurons in response to α-MSH (200-300 ng, i.c.v.). B1, Inhibition of a representative oxytocin neuron (identified by its activation after intravenous injection of 20 μg/kg CCK) in response to MC4R agonist (100 ng, i.c.v.). B2-B4, The inhibition induced by MC4R agonist is dose-dependent. Data show the mean changes in firing rate (± SE) after MC4R agonist at 50-100 ng (MC4R ago-1; n = 6; B2), 200 ng (MC4R ago-2; n = 6; B3), and 400-500 ng (MC4R ago-3; n = 5; B4).