Figure 7.

Decreased anxiety in L1fy+ mice in the elevated plus-maze. L1fy+ mice showed a higher propensity to explore the open arm of the elevated plus-maze as compared with their L1fy- littermates, whereas their general locomotor activity was unchanged. A, No difference in total transitions (entries into the open and closed arms) was detected between the two genotypes. B, Both genotypes showed ∼10 entries into the closed arms. C, L1fy+ mice spent less time (percentage), as compared with L1fy- littermates, in risk assessment toward the open arms while staying in the protected areas (closed arms and center). D, L1fy+ mice entered the open arms with lower latencies as compared with L1fy- littermates. The latencies of each mouse are shown, and the median values are indicated with a line. E, L1fy+ mice entered more often the open arms (percentage of open arm entries and open and closed arms entries) as compared with L1fy- littermates. F, L1fy+ mice spent more time (percentage) on the open arms as compared with L1fy- littermates. Each value represents the genotype mean ± SEM, except for C, where single data points are shown. ^*p < 0.05, ^**p < 0.01, respectively, as compared with L1fy- mice (Mann-Whitney U test).