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. 2003 Nov 12;23(32):10419–10432. doi: 10.1523/JNEUROSCI.23-32-10419.2003

Figure 9.

Figure 9.

Altered use of visuospatial information in L1fy+ mice in the water-maze experiments 2 and 3. A-C, Results from experiment 2. A, Path length during acquisition in the hidden platform test. On days 8 and 9 the black stripes were absent, where as on days 10-11 they were present and the landmarks were absent. For all the other days the room was as shown in B. Each value represents the mean of two consecutive trials. L1fy+ mice needed longer paths to find the platform as compared with L1fy- littermates in the first two trials of day 8, immediately after the stripes were removed from the corners. B, Schematic representation of the experimental room. The gray sections plus the four areas represent the ring. The dotted lines represent white curtains. The positions of landmarks and black stripes at the walls and corners are schematized. Two perpendicular lines divide the pool into four quadrants (NE, NW, SE, SW). ANE, ASE, ASW, and ANW are the four areas with a diameter of 28 cm, twice the diameter of the platform. The platform was located in the center of areas ANW. C, The ability to search the platform within a small area is tested for the seven transfer trials by calculating the time (percentage) spent in the target area surrounding the platform. Although L1fy- mice always had a preference for the target area, L1fy+ mice stayed less time in the target area on the transfer trials on day 8 (stripes absent) and on day 17 (5 d after the last training). D, E, Results from Experiment 3. D, Path length during acquisition of the hidden platform protocol during experiment 3 when two landmarks were located on a black circular curtain surrounding the pool. Each value represents the mean of two consecutive trials. On training days 31-32 the platform was located in SE and on days 33-34 it was in SW. L1fy+ mice needed longer path lengths to find the platform on days 31 and 32 but not on days 33 and 34, when the platform was near one of the landmarks. E, Time spent in the target area during the transfer trials performed at the end of training days 32 and 34. L1fy+ mice spent less time as compared with L1fy- mice in the target area during both transfer trials. Each value represents the genotype mean ± SEM. +p < 0.01 and ++p < 0.001, respectively, as compared with L1fy- mice for the same trial or day; *p < 0.05 and **p < 0.01, respectively, as compared with the previous day within the same genotype (Newman-Keuls post hoc test after a significant effect of the interaction between genotype and day). #p < 0.05 and ##p < 0.01, respectively, as compared with L1fy- mice (Mann-Whitney U test).