Figure 2.

Effects of THC on corticostriatal neurotransmission. Application of 10 μm THC induced a slowly developing, long-lasting depression in population spike amplitude (a). When applied in the presence of CB₁ receptor antagonists, 100 nmSR141716 (b) or 500 nm AM251 (c), THC no longer depressed population spike amplitude. The persistent depression induced by application of THC was partially restored by subsequent application of AM251 (d). In this and subsequent figures, inset traces (1-5) represent the average of four individual responses from a typical experiment at the indicated time points, and data points represent the average response each minute from four to seven separate experiments.