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Effects of mGluR activation on corticostriatal neurotransmission. Application of THC (a) or THA (b) no longer reduced population spike amplitude when applied in the presence of the broad-spectrum mGluR antagonist LY341495. Depressions in population spike amplitude induced by agonists of group III, l-AP-4 (c), and group II, (2R,4R)-APDC (d), mGluRs were also prevented by LY341495.
