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. 2003 Dec 3;23(35):11112–11119. doi: 10.1523/JNEUROSCI.23-35-11112.2003

Figure 2.

Figure 2.

Phenotypic features of excess cells seen in the bax-/-bak-/- compared with wild-type mouse brains. Cells in the SVZ were phenotyped by immunohistochemistry. In the bax-/-bak-/- SVZ, 16.9 ± 3.1% of the cells labeled with the neuronal marker NeuN, labeling immature and mature neurons, whereas 11.2 ± 3.1% of the cells expressed the low molecular weight neurofilament proteins (NFP). Among the small immature cells, 13.4 ± 1.3% cells showed astrocytic differentiation (GFAP labeling). A total of 13.7 ± 2.8% NeuN-positive, 7.3 ± 1.3% NFP-positive, and 3.1 ± 0.5% GFAP-positive cells were present in the SVZ of wild-type mice. Immunofluorescence was used to demonstrate the expression of the intermediate filament nestin found in immature neurons within the SVZ (red; nuclear counter stain with DAPI, blue). Scale bar, 75 μm.